The Prolyl Isomerase Pin1 Regulates the NF-κB Signaling Pathway and Interleukin-8 Expression in Glioblastoma

@inproceedings{Atkinson2009ThePI,
  title={The Prolyl Isomerase Pin1 Regulates the NF-κB Signaling Pathway and Interleukin-8 Expression in Glioblastoma},
  author={George P. Atkinson and Susan E Nozell and David K. Harrison and Mark S. Stonecypher and Dongquan Chen and Etty Nadia Benveniste},
  booktitle={Oncogene},
  year={2009}
}
The brain tumor glioblastoma (GBM) remains one of the most aggressive and devastating tumors despite decades of effort to find more effective treatments. A hallmark of GBM is the constitutive activation of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway, which regulates cell proliferation, inflammation, migration and apoptosis. The prolyl isomerase, Pin1, has been found to bind directly to the NF-κB protein, p65, and cause increases in NF-κB promoter… CONTINUE READING