The Proinflammatory Mediators C3a and C5a Are Essential for Liver Regeneration

@article{Strey2003ThePM,
  title={The Proinflammatory Mediators C3a and C5a Are Essential for Liver Regeneration},
  author={Christoph W. Strey and Maciej M Markiewski and Dimitrios C. Mastellos and Ruxandra Tudoran and Lynn A. Spruce and Linda E. Greenbaum and John D. Lambris},
  journal={The Journal of Experimental Medicine},
  year={2003},
  volume={198},
  pages={913 - 923}
}
Complement has been implicated in liver repair after toxic injury. Here, we demonstrate that complement components are essential for liver regeneration, and mediate their effect by interacting with key signaling networks that promote hepatocyte proliferation. C3- or C5-deficient mice exhibited high mortality, parenchymal damage, and impaired liver regeneration after partial hepatectomy. Mice with dual C3 and C5 deficiency had a more exacerbated phenotype that was reversed by combined C3a and… CONTINUE READING

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