The Prohibitins: emerging roles in diverse functions

  title={The Prohibitins: emerging roles in diverse functions},
  author={Suresh Mishra and Leigh C. Murphy and Liam J. Murphy},
  booktitle={Journal of cellular and molecular medicine},
The prohibitins, Phb1 and Phb2 are highly conserved proteins in eukaryotic cells that are present in multiple cellular compartments. Initial investigations focused on the role of Phb1 as an inhibitor of cell proliferation hence the original name prohibitin. However both proteins appear to have a diverse range of functions and recent evidence suggests that the prohibitins have very similar but as yet only partially understood functions. In addition to their role as chaperone proteins in the… CONTINUE READING
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