The Prohead-I structure of bacteriophage HK97: implications for scaffold-mediated control of particle assembly and maturation.

@article{Huang2011ThePS,
  title={The Prohead-I structure of bacteriophage HK97: implications for scaffold-mediated control of particle assembly and maturation.},
  author={Rick K. Huang and Reza Khayat and Kelly K. Lee and Ilya Gertsman and Robert L. Duda and Roger W. Hendrix and John E. Johnson},
  journal={Journal of molecular biology},
  year={2011},
  volume={408 3},
  pages={541-54}
}
Virus capsid assembly requires recruiting and organizing multiple copies of protein subunits to form a closed shell for genome packaging that leads to infectivity. Many viruses encode scaffolding proteins to shift the equilibrium toward particle formation by promoting intersubunit interactions and stabilizing assembly intermediates. Bacteriophage HK97 lacks an explicit scaffolding protein, but the capsid protein (gp5) contains a scaffold-like N-terminal segment termed the delta domain. When gp5… CONTINUE READING

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