The Prognostic Significance of p 16 INK 4 a / p 14 ARF and p 15 INK 4 b Deletions in Adult Acute Lymphoblastic Leukemia

@inproceedings{Faderl1999ThePS,
  title={The Prognostic Significance of p 16 INK 4 a / p 14 ARF and p 15 INK 4 b Deletions in Adult Acute Lymphoblastic Leukemia},
  author={Stefan Faderl and Hagop M Kantarjian and Taghi Manshouri and Chin-Yung Chan and Sherry Pierce and Kimberly J. Hays and Jorge Cortes and Deborah Thomas and Zeev Estrov and Maher Albitar},
  year={1999}
}
Cytogenetic/molecular abnormalities significantly influence the prognosis of patients with acute leukemia. Recently, two genes, p16 INK4a and p15, encoding two cyclin-dependent kinase inhibitor proteins of the INK4 family of M r 15,000 and 16,000, respectively, have been localized to 9p21. Remarkably, thep16 locus has been found to encode a second protein, p14 , known as p19 in mice, with a distinct reading frame. Like p16, p14 is involved in cell cycle regulation, blocking cells at the G1… CONTINUE READING