The Prognostic Power of the NOD2 Genotype for Complicated Crohn's Disease: A Meta-Analysis

  title={The Prognostic Power of the NOD2 Genotype for Complicated Crohn's Disease: A Meta-Analysis},
  author={Jeremy Adler and Sujal C. Rangwalla and Ben A. Dwamena and Peter D. Higgins},
  journal={The American Journal of Gastroenterology},
OBJECTIVES:Crohn's disease is often purely inflammatory at presentation, but most patients develop strictures and fistulae over time (complicated disease). Many studies have suggested that nucleotide-binding oligomerization domain 2 (NOD2) mutations are associated with a varying but increased risk of complicated disease. An accurate and sufficiently powerful predictor of complicated disease could justify the early use of biological therapy in high-risk individuals. We performed a systematic… CONTINUE READING


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