The Prognostic Power of the NOD2 Genotype for Complicated Crohn's Disease: A Meta-Analysis

@article{Adler2011ThePP,
  title={The Prognostic Power of the NOD2 Genotype for Complicated Crohn's Disease: A Meta-Analysis},
  author={Jeremy Adler and Sujal C. Rangwalla and Ben A. Dwamena and Peter D. Higgins},
  journal={The American Journal of Gastroenterology},
  year={2011},
  volume={106},
  pages={699-712}
}
OBJECTIVES:Crohn's disease is often purely inflammatory at presentation, but most patients develop strictures and fistulae over time (complicated disease). Many studies have suggested that nucleotide-binding oligomerization domain 2 (NOD2) mutations are associated with a varying but increased risk of complicated disease. An accurate and sufficiently powerful predictor of complicated disease could justify the early use of biological therapy in high-risk individuals. We performed a systematic… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 84 references

Th e presence of fi stulas and NOD 2 homozygosity strongly predict intestinal stenosis in Crohn ’ s disease independent of the IL 23 R genotype

M Jurgens, S Brand, RP Laubender
J Gastroenterol • 2010

Evaluation of the association of NOD2/CARD15 gene polymorphisms with clinical course of Turkish Crohn’s disease patients

O Ozutemiz
Int J Med Med Sci • 2009

Identifi cation of NOD 2 / CARD 15 mutations in Malaysian patients with Crohn ’ s disease

KH Chua, I Hilmi, CC Ng
J Dig Dis • 2009

Phenotypic associations of Crohn ’ s disease with antibodies to fl agellins A 4 - Fla 2 and FlaX , ASCA , pANCA , PAB , and NOD 2 mutations in a Swiss Cohort

AM Schoepfer, T Schaffer, S Mueller
Infl amm Bowel Dis • 2009

CARD 15 and IL 23 R infl uences Crohn ’ s disease susceptibility but not disease phenotype in a Brazilian population

ML Baptista, H Amarante, G Picheth
Infl amm Bowel Dis • 2008

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