The Production of Reactive Oxygen Species in Intact Isolated Nerve Terminals Is Independent of the Mitochondrial Membrane Potential

@article{Sipos2003ThePO,
  title={The Production of Reactive Oxygen Species in Intact Isolated Nerve Terminals Is Independent of the Mitochondrial Membrane Potential},
  author={I. R{\'o}bert Sipos and L{\'a}szl{\'o} Tretter and Vera {\'A}d{\'a}m-Vizi},
  journal={Neurochemical Research},
  year={2003},
  volume={28},
  pages={1575-1581}
}
Dependence on mitochondrial membrane potential (ΔΨm) of hydrogen peroxide formation of in situ mitochondria in response to inhibition of complex I or III was studied in synaptosomes. Blockage of electron flow through complex I by rotenone or that through complex III by antimycin resulted in an increase in the rate of H2O2 generation as measured with the Amplex red assay. Membrane potential of mitochondria was dissipated by either FCCP (250 nM) or DNP (50 mM) and then the rate of H2O2 production… CONTINUE READING
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