The Production of Bactericidal Substances by Aerobic Sporulating Bacilli

  title={The Production of Bactericidal Substances by Aerobic Sporulating Bacilli},
  author={Ren{\'e} J. Dubos and Rollin H. Hotchkiss},
  journal={The Journal of Experimental Medicine},
  pages={629 - 640}
Several species of aerobic sporulating bacilli recently isolated from soil, sewage, manure, and cheese, as well as authentic strains obtained from type culture collections, have been found to exhibit antagonistic activity against unrelated microorganisms. Cultures of these aerobic sporulating bacilli yield an alcohol-soluble, water-insoluble fraction,-tyrothricin,-which is bactericidal for most Gram-positive and Gram-negative microbial species. Two different crystalline products have been… CONTINUE READING

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