The Production of Antibody by Invading B Cells Is Required for the Clearance of Rabies Virus from the Central Nervous System

@inproceedings{Hooper2009ThePO,
  title={The Production of Antibody by Invading B Cells Is Required for the Clearance of Rabies Virus from the Central Nervous System},
  author={D Craig Hooper and Timothy W. Phares and Marzena Jolanta Fabis and Anirban Roy},
  booktitle={PLoS neglected tropical diseases},
  year={2009}
}
BACKGROUND The pathogenesis of rabies is associated with the inability to deliver immune effectors across the blood-brain barrier and to clear virulent rabies virus from CNS tissues. However, the mechanisms that facilitate immune effector entry into CNS tissues are induced by infection with attenuated rabies virus. METHODOLOGY/PRINCIPAL FINDINGS Infection of normal mice with attenuated rabies virus but not immunization with killed virus can promote the clearance of pathogenic rabies virus… CONTINUE READING

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The role of immune response in the pathogenesis of rabies

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