The Production Rate of Cortisol in Man

@article{Cope1958ThePR,
  title={The Production Rate of Cortisol in Man},
  author={C. Cope and E. Black},
  journal={British Medical Journal},
  year={1958},
  volume={1},
  pages={1020 - 1024}
}
have the picture of normal haem-that is, iron protoporphyrin-together with masses of uroporphyrin I and coproporphyrin I, the end stages of the abnormal synthesis proceeding in some erythrocytes. To understand this situation in more detail it is necessary to recall what is now known about the biochemistry of porphyrin synthesis, and this I have summarized in Fig. 2. Glycine and succinic acid are the two simple materials from which the complex ring structure of porphyrin is built up. An initial… Expand

Topics from this paper

METABOLISM OF ADRENOCORTICOSTEROIDS IN MAN
  • R. E. Peterson
  • Chemistry, Medicine
  • Annals of the New York Academy of Sciences
  • 1959
TLDR
The purpose of this paper to summarize the present knowledge of the metabolism of these three natural adrenocorticoids: cortisol, corticosterone, and aldosterone. Expand
Introduction and removal of hydrocortisone from plasma. Rates in normal subjects and anxious patients.
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  • Psychology, Medicine
  • Archives of general psychiatry
  • 1962
TLDR
A large number of physical and psychological stresses have been shown to increase adrenocortical secretion, and increased responsivity to corticotropin (ACTH) in subjects under the disturbing condition has chiefly consisted in demonstrating increased plasma hydrocortisone levels. Expand
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  • C. Cope, E. Black
  • Medicine
  • The Journal of obstetrics and gynaecology of the British Empire
  • 1959
TLDR
Findings justify the conclusion that adrenal cortical activity is probably raised in pregnancy and the magnitude of this increase has remained a matter of conjecture. Expand
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Observations indicate that a larger part of cortisol remains as a biologically active form in plasma and may result in the increased urinary 11-OH metabolites in patients with infectious and collagen diseases. Expand
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  • F. Prunty
  • Medicine
  • Proceedings of the Royal Society of Medicine
  • 1958
TLDR
It would be superfluous to mention all the hormones which can now be estimated in blood with an acceptable degree of accuracy, but they include some such as insulin, corticotropin and thyrotropin dependent still on bio-assay techniques, and others such as steroids and catechol amines where chemical methods may be accurately applied. Expand
Laboratory investigation of the human hypothalamic-pituitary-adrenocortical system.
TLDR
It is shown that the adrenal cortex in man, as far as cortisol production is concerned, shows little impairment even in advanced age, and is susceptible to failure on account of treatment which the patient may receive at the hands of the doctor, the so-called iatrogenic adrenocortical insufficiency. Expand
Secretion of steroid hormones in vivo.
TLDR
This chapter discusses the secretion of steroid hormones in vivo, and shows that the enzymes needed for steroid biosynthesis are present in all steroid-forming organs and that the distinctive secretory products of different glands are reflected by differences in the activities of appropriate enzymes. Expand
Some aspects of the measurement of cortisol production in patients with breast cancer.
TLDR
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Produktion und Stoffwechsel von Corticosteroiden und Androgenen bei der Lebercirrhose
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It is demonstrated that in patients with cirrhosis of the liver, conclusions on the function of the adrenals and the gonads, based on results of urinary analysis of steroid hormones, are limited. Expand
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