The Principal Genetic Determinants for Nasopharyngeal Carcinoma in China Involve the HLA Class I Antigen Recognition Groove

@inproceedings{Tang2012ThePG,
  title={The Principal Genetic Determinants for Nasopharyngeal Carcinoma in China Involve the HLA Class I Antigen Recognition Groove},
  author={Minzhong Tang and J. A. Lautenberger and Xiaojiang Gao and E Sezgin and Sher L. Hendrickson and Jennifer L. Troyer and Victor A. David and Li Guan and Carl E. Mcintosh and Xiuchan Guo and Yu-Ming Zheng and Jian Liao and Hong Kui Deng and Michael J Malasky and Bailey D Kessing and Cheryl A. Winkler and Mary Carrington and Guy d{\'e} The and Yi Zeng and Stephen J. O'Brien},
  booktitle={PLoS genetics},
  year={2012}
}
Nasopharyngeal carcinoma (NPC) is an epithelial malignancy facilitated by Epstein-Barr Virus infection. Here we resolve the major genetic influences for NPC incidence using a genome-wide association study (GWAS), independent cohort replication, and high-resolution molecular HLA class I gene typing including 4,055 study participants from the Guangxi Zhuang Autonomous Region and Guangdong province of southern China. We detect and replicate strong association signals involving SNPs, HLA alleles… CONTINUE READING
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