The Primary Cilium as the Cell's Antenna: Signaling at a Sensory Organelle

@article{Singla2006ThePC,
  title={The Primary Cilium as the Cell's Antenna: Signaling at a Sensory Organelle},
  author={Veena Singla and J. F. Reiter},
  journal={Science},
  year={2006},
  volume={313},
  pages={629 - 633}
}
  • Veena Singla, J. F. Reiter
  • Published 2006
  • Biology, Medicine
  • Science
  • Almost every vertebrate cell has a specialized cell surface projection called a primary cilium. Although these structures were first described more than a century ago, the full scope of their functions remains poorly understood. Here, we review emerging evidence that in addition to their well-established roles in sight, smell, and mechanosensation, primary cilia are key participants in intercellular signaling. This new appreciation of primary cilia as cellular antennae that sense a wide variety… CONTINUE READING
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