The Prevention of Chronic Postsurgical Pain Using Gabapentin and Pregabalin: A Combined Systematic Review and Meta-Analysis

@article{Clarke2012ThePO,
  title={The Prevention of Chronic Postsurgical Pain Using Gabapentin and Pregabalin: A Combined Systematic Review and Meta-Analysis},
  author={Hance A Clarke and Robert P. Bonin and Beverley A. Orser and Marina F Englesakis and Duminda N. Wijeysundera and Joel Katz},
  journal={Anesthesia \& Analgesia},
  year={2012},
  volume={115},
  pages={428–442}
}
BACKGROUND:Many clinical trials have demonstrated the effectiveness of gabapentin and pregabalin administration in the perioperative period as an adjunct to reduce acute postoperative pain. However, very few clinical trials have examined the use of gabapentin and pregabalin for the prevention of chronic postsurgical pain (CPSP). We (1) systematically reviewed the published literature pertaining to the prevention of CPSP (≥2 months after surgery) after perioperative administration of gabapentin… Expand

Paper Mentions

Interventional Clinical Trial
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a condition that results in long-term bladder and pelvic pain. IC/BPS affects women more often than men. How the disorder… Expand
ConditionsBladder Pain Syndrome, Interstitial Cystitis
InterventionDrug
Interventional Clinical Trial
The purpose of the investigators' study is to assess the efficacy of a single dose of preoperative gabapentin within an enhanced recovery after surgery protocol in acute… Expand
ConditionsPain, Postoperative
InterventionDrug
Interventional Clinical Trial
The purpose of this study is to prospectively determine the influence of immediate pre-operative gabapentin administration on acute postoperative pain. The investigators… Expand
ConditionsPostoperative Pain
InterventionDrug, Other
Perioperative pregabalin administration does not prevent chronic postoperative pain: systematic review with a meta-analysis of randomized trials
TLDR
Pooled data from published and unpublished studies provide no support for the efficacy of pregabalin for preventing CPSP, according to a random-effect meta-analysis. Expand
Perioperative use of pregabalin for acute pain—a systematic review and meta-analysis
TLDR
Pregabalin analgesic effectiveness is largely restricted to surgical procedures associated with pronociceptive mechanisms and the clinical significance of observed pregabalin benefits must be weighed against the uncertainties about serious harms and enhanced recovery to inform the careful selection of surgical patients. Expand
A protocol for a systematic review for perioperative pregabalin use
TLDR
This systematic review protocol will attempt to bridge the growing gap between clinical experience and emerging evidence, and has the potential to aid future guideline development in the perioperative use of pregabalin. Expand
Perioperative Use of Gabapentinoids for the Management of Postoperative Acute Pain: A Systematic Review and Meta-analysis.
TLDR
The routine use of pregabalin or gabapentin for the management of postoperative pain in adult patients is not supported, as no clinically significant analgesic effect for the perioperative use of gABapentinoids was observed and there was also no effect on the prevention of post operative chronic pain and a greater risk of adverse events. Expand
A Meta-Analysis on the Use of Gabapentinoids for the Treatment of Acute Postoperative Pain Following Total Knee Arthroplasty.
TLDR
A meta-analysis of randomized controlled trials of patients undergoing elective primary total knee arthroplasty found no evidence to support the routine use of gabapentinoids in the management of acute pain following total kneeArthroplastic surgery. Expand
Preoperative pregabalin or gabapentin for acute and chronic postoperative pain among patients undergoing breast cancer surgery: A systematic review and meta-analysis of randomized controlled trials.
TLDR
Gabapentin and pregabalin administered perioperatively in patients undergoing breast cancer surgery improve acute postoperative pain as indicated by the reduction in opioid consumption, and seem to reduce opioid consumption in the recovery room. Expand
Impact of Pregabalin on the Occurrence of Postthoracotomy Pain Syndrome: A Randomized Trial
TLDR
Among patients with PTPS, those in the pregabalin group required significantly less analgesics, reported less moderate to severe average pain, and presented significantly less neuropathic characteristics than patients in the placebo group 3 months after surgery. Expand
Perioperative Use of Gabapentinoids for the Management of Postoperative Acute Pain.
TLDR
The routine use of pregabalin or gabapentin for the management of postoperative pain in adult patients is not supported, as no clinically significant analgesic effect was observed and there was also no effect on the prevention of post operative chronic pain and a greater risk of adverse events. Expand
[Perioperative gabapentin and pregabalin in cardiac surgery: a systematic review and meta-analysis].
TLDR
There is insufficient evidence to recommend routine use of gabapentin and pregabalin to reduce opioid consumption in the cardiac surgical patients, and the drugs are not associated with any significant complications. Expand
Intra- and postoperative intravenous ketamine does not prevent chronic pain: A systematic review and meta-analysis
TLDR
There is currently not sufficient evidence to support a reduction in chronic pain due to perioperative administration of ketamine, and it can be hypothesised, that regional anaesthesia in addition to the administration of perioperatively ketamine might have a preventive effect on the development of persistent postsurgical pain. Expand
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