The Presence of Small Intestinal Intraepithelial Gamma/Delta T-Lymphocytes Is Inversely Correlated With Lymphoma Development in Refractory Celiac Disease

@article{Verbeek2008ThePO,
  title={The Presence of Small Intestinal Intraepithelial Gamma/Delta T-Lymphocytes Is Inversely Correlated With Lymphoma Development in Refractory Celiac Disease},
  author={Wieke H. M. Verbeek and B. Mary E. von Blomberg and Petra E. T. Scholten and Dirk Joop Kuik and Chris Jacob Johan Mulder and Marco W J Schreurs},
  journal={The American Journal of Gastroenterology},
  year={2008},
  volume={103},
  pages={3152-3158}
}
BACKGROUND:In refractory celiac disease (RCD) type II, a phenotypically aberrant (CD7+ CD3− CD4/8-cytoplasmicCD3+) intraepithelial lymphocyte (IEL) population is present, and 50–60% of these patients develop enteropathy-associated T-cell lymphoma (EATL). TCRγδ+ IELs play an important role in mucosal repair, homeostasis, and tumor surveillance. Recently, human small intestinal TCRγδ+ IELs were shown to have regulatory potential in uncomplicated celiac disease (CD).AIM:In the present study, we… CONTINUE READING