The Presence of IL-17A and T Helper 17 Cells in Experimental Mouse Brain Tumors and Human Glioma

@inproceedings{Wainwright2010ThePO,
  title={The Presence of IL-17A and T Helper 17 Cells in Experimental Mouse Brain Tumors and Human Glioma},
  author={Derek A. Wainwright and Sadhak Sengupta and Yu Han and Ilya V Ulasov and Maciej S. Lesniak},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Recently, CD4(+)IL-17A(+) T helper 17 (Th17) cells were identified and reported in several diseased states, including autoimmunity, infection and various peripheral nervous system tumors. However, the presence of Th17 in glia-derived tumors of the central nervous system has not been studied. METHODOLOGY/PRINCIPAL FINDINGS In this report, we demonstrate that mRNA expression for the Th17 cell cytokine IL-17A, as well as Th17 cells, are present in human glioma. The mRNA expression for… CONTINUE READING
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