The Preparation of High-content Gemcitabine pH Sensitive Liposomes and Evaluation of their Cytotoxicity to Drug Resistant Pancreatic Cancer Cells

SUMMARY Gemcitabine containing pH sensitive liposomes (PSL) has been prepared using a Small Volume Incubation (SVI) method. The entrapment efficiency (EE) and drug loading (DL) were 29.5 ± 0.2% and 4.2 ± 0.2%, a respective 7and 70-fold increase compared to the thin film hydration extrusion (TFHE) method. The particle size and zeta potential were 146 ± 2 nm… (More)

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