The Preparation and Function of the Hypertensin-converting Enzyme

@article{Skeggs1956ThePA,
  title={The Preparation and Function of the Hypertensin-converting Enzyme},
  author={Leonard T. Skeggs and Joseph R. Kahn and Norman P. Shumway},
  journal={The Journal of Experimental Medicine},
  year={1956},
  volume={103},
  pages={295 - 299}
}
It has been shown by use of isolated, perfused rat kidneys that hypertensin II is a potent vasoconstrictor substance while hypertensin I is not. Hence it would appear that in intact animals the pressor activity of hypertensin I results from its rapid conversion to hypertensin II. An enzyme which effects this conversion has been procured from horse plasma in a semipurified form by means of ammonium sulfate fractionation and isoelectric precipitation. A method is described for estimating the… CONTINUE READING