The Premonitory Symptoms (Prodrome): A Tertiary Care Study of 893 Migraineurs

  title={The Premonitory Symptoms (Prodrome): A Tertiary Care Study of 893 Migraineurs},
  author={Leslie Kelman},
  journal={Headache: The Journal of Head and Face Pain},
  • L. Kelman
  • Published 1 October 2004
  • Medicine, Psychology
  • Headache: The Journal of Head and Face Pain
Objectives.—This study of premonitory symptoms in migraine was performed to document the frequency, duration, and types of symptoms in a large group of migraine patients. 

Trigger Factors and Premonitory Features of Migraine Attacks: Summary of Studies

In this second of a 2‐part series, we review the available literature on trigger factors and premonitory features in migraine.

Methodological Issues in Studying Trigger Factors and Premonitory Features of Migraine

In this review, we focus on migraine as a chronic disorder with episodic attacks (CDEA). We aim to review methodological approaches to studying trigger factors and premonitory features that often

Prospective Analysis of Factors Related to Migraine Aura – The PAMINA Study

The aim of this study was to examine factors increasing and decreasing the risk of occurrence of migraine aura and of headache and migraine not associated with aura prospectively by means of a daily diary.

Key Concepts of Migraine Postdrome: A Qualitative Study to Develop a Post‐Migraine Questionnaire

(Headache 2011;51:105‐117)

Migraine After Sneezing: Pathophysiological Considerations, Focused on the Difference With Coughing

In patients reporting acute headache after sneezing or coughing, rupture of an intracranial aneurysm is the first diagnosis to be considered. Sneezing, however, might also be a trigger for migraine

Rizatriptan Efficacy in ICHD‐II Pure Menstrual Migraine and Menstrually Related Migraine

The objective is to examine the efficacy of rizatriptan for the treatment of pure menstrual migraine (PMM) and to establish an experimental protocol for this treatment.

Reliability of assessing lifestyle and trigger factors in patients with migraine – findings from the PAMINA study

Rec retrospective and prospective assessments of lifestyle in general and of migraine triggers in particular were compared in patients with migraine to assess the reliability of these assessments retrospectively.

Longitudinal Neuroimaging over 30 Days: Temporal Characteristics of Migraine

The premonitory phase of migraine is characterized by a well‐described complex of symptoms, but its duration is not clearly defined, and there are no biomarkers to help define when this phase starts.

Can Migraineurs Accurately Identify Their Headaches as “Migraine” at Attack Onset?

Background.—While treating migraine early when the headache is mild is believed to link to improved treatment outcomes, it is not clear whether patients can correctly self‐identify a headache as a



Sumatriptan for the Range of Headaches in Migraine Sufferers: Results of the Spectrum Study

A small number of patients with a history of migraine and/or episodic tension‐type headaches are diagnosed with atypical or chronic migrainous headaches and receive treatment with anti-inflammatory medication.

Treatment of Mild Headache in Disabled Migraine Sufferers: Results of the Spectrum Study

Evaluation of the effectiveness of sumatriptan, 50‐mg tablets, versus placebo for early intervention while head pain was mild in patients with disabling migraine found it to be safe and effective.

Migraine prodromes separated from the aura: complete migraine.

  • J. N. Blau
  • Psychology, Medicine
    British medical journal
  • 1980
Detailed questioning of 50 patients with uncomplicated migraine has shown that 17 had symptoms that preceded the headache phase by several hours, and the term "complete migraine" is proposed for attacks that include prodromal symptoms.

Premonitory symptoms in migraine without aura: a clinical investigation.

It is hypothesized that patients with migraine attacks generally preceded by premonitory symptoms have a stronger constitutional migraine trait with a premature weakening of their antinociceptive adaptation systems to the environment and to stressful events.

Triptans for Migraine Prodrome

This patient suffers from migraine without aura, which should be distinguished from migraine aura, with the latter involving focal neurologic symptoms which typically develop gradually over 5 to 20 minutes, last less than 60 minutes, and are followed by headache within an hour.

Migraine With Aura and Migraine Without Aura: An Epidemiological Study

The present findings suggest that MA and MO share the pain phase, and headache was, however, less severe and shorter lasting in MA than in MO.

Warning Symptoms in Migraine: Characteristics and Therapeutic Implications

  • J. Waelkens
  • Psychology
    Cephalalgia : an international journal of headache
  • 1985
The data suggest that the mechanism leading to a migraine attack can be operative 8–48 h before the headache begins and is possibly dopaminergically mediated.

Clinical Benefits of Early Triptan Therapy for Migraine

With early intervention with triptans, pain was less likely to intensify, fewer attacks required redosing, more attacks remained pain‐free 24 hours postdose, and normal function returned more quickly.

Triptans in migraine

In general practice, triptan treatment in migraine does not increase the risk of stroke, MI, cardiovascular death, IHD, or mortality, and triptans are prescribed to those less at risk of these events.