The Prediction of Human Exons By Oligonucleotide Composition and Disriminant Analysis of Spliceable Open Reading Frames

@article{Solovyev1994ThePO,
  title={The Prediction of Human Exons By Oligonucleotide Composition and Disriminant Analysis of Spliceable Open Reading Frames},
  author={Victor V. Solovyev and Asaf A. Salamov and Charles B. Lawrence},
  journal={Proceedings. International Conference on Intelligent Systems for Molecular Biology},
  year={1994},
  volume={2},
  pages={354-62}
}
Discriminant analysis is applied to the problem of recognition 5'-, internal and 3'-exons in human DNA sequences. Specific recognition functions were developed for revealing exons of particular types. The method based on a splice site prediction algorithm that uses the linear Fisher discriminant to combine the information about significant triplet frequencies of various functional parts of splice site regions and preferences of oligonucleotides in protein coding and intron regions (Solovyev… CONTINUE READING