The Precursor to Glutathione (GSH), γ-Glutamylcysteine (GGC), Can Ameliorate Oxidative Damage and Neuroinflammation Induced by Aβ40 Oligomers in Human Astrocytes

  title={The Precursor to Glutathione (GSH), $\gamma$-Glutamylcysteine (GGC), Can Ameliorate Oxidative Damage and Neuroinflammation Induced by A$\beta$40 Oligomers in Human Astrocytes},
  author={Nady Braidy and Martin Hani Zarka and Bat-Erdene Jugder and Jeffrey H. Welch and Tharusha Jayasena and Daniel Kam Yin Chan and Perminder Singh Sachdev and Wallace John Bridge},
  journal={Frontiers in Aging Neuroscience},
Glutathione (GSH) is one of the most abundant thiol antioxidants in cells. Many chronic and age-related diseases are associated with a decline in cellular GSH levels or impairment in the catalytic activity of the GSH biosynthetic enzyme glutamate cysteine ligase (GCL). γ-glutamylcysteine (GGC), a precursor to glutathione (GSH), can replenish depleted GSH levels under oxidative stress conditions, by circumventing the regulation of GSH biosynthesis and providing the limiting substrate. Soluble… 

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