The Potential of Nucleotide Analogs as Inhibitors of Retroviruses and Tumors

@article{Robins1984ThePO,
  title={The Potential of Nucleotide Analogs as Inhibitors of Retroviruses and Tumors},
  author={Roland K. Robins},
  journal={Pharmaceutical Research},
  year={1984},
  volume={1},
  pages={11-18}
}
The biologically active form of most purine or pyrimidine analogs is the nucleoside 5′-mono, di- or triphosphate. The nucleoside form is most often administered because of the ease with which it penetrates cells by facilitated transport. However, many nucleoside derivatives fail to exhibit significant antiviral or antitumor activity because they are not phosphorylated by cellular enzymes to the active nucleotide form. In this review, the potential use of suitable nucleotide analogs as selective… CONTINUE READING