The Potential of Moringa oleifera to Induce Cerebral Leptin mRNA Expression and to Attenuate Oxidative Stress, Cognitive and Motor Deficits, Depression- and Anxiety- Like Behavior in Experimental Obese Model

@article{Mahmoud2017ThePO,
  title={The Potential of Moringa oleifera to Induce Cerebral Leptin mRNA Expression and to Attenuate Oxidative Stress, Cognitive and Motor Deficits, Depression- and Anxiety- Like Behavior in Experimental Obese Model},
  author={Asmaa Ahmed Mahmoud and Fateheya Mohamed Metwally and Hend Rashad and Hanaa H. Ahmed and Asmaa M Elfiky and Aboelfetoh Mohamed Abdalla},
  journal={Pharmaceutical and Clinical Research},
  year={2017},
  volume={9}
}
Moringa oleifera showed an evident role against obesity and leptin resistance. However, Moringa oleifera potential effects on alteration of moods, cognitive as well as motor deficits in obese animal model have not been evaluated in a mechanistic way. So, the aim of the current study is to examine the potential of Moringa oleifera to induce cerebral leptin mRNA expression, and consequently its effects on amelioration of behavioral and biochemical alterations in obese female rats. Ethanolic… Expand
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References

SHOWING 1-10 OF 61 REFERENCES
Molecular mechanisms of the anti-obesity potential effect of Moringa oleifera in the experimental model
TLDR
It is reasonable to assume that the anti-obesity, anti-atherogenic and anti-diabetic properties of M. oleifera are mechanistically achieved via working directly on the adipokines of the visceral adipose tissue, and may be a good therapeutic candidate for the symptoms of metabolic syndrome. Expand
Imbalance of leptin pathway and hypothalamus synaptic plasticity markers are associated with stress-induced depression in rats
TLDR
The results demonstrated that the mRNA expression of synaptotagmin I, but not synapsin I, was correlated with the depression-like behaviors and HPA axis hyperactivity in CUMS rats, suggesting that a CUMS rat model could be effectively used to study molecular mechanisms underling the depressive symptomatology. Expand
QCM-4, a 5-HT₃ receptor antagonist ameliorates plasma HPA axis hyperactivity, leptin resistance and brain oxidative stress in depression and anxiety-like behavior in obese mice.
TLDR
QCM-4 showed antidepressive and anxiolytic effect by reversing the behavioral alterations that were supported by biochemical estimations in obese mice. Expand
The Effects of High-fat-diet Combined with Chronic Unpredictable Mild Stress on Depression-like Behavior and Leptin/LepRb in Male Rats
TLDR
Depressive and anxiety-like behaviors as well as cognitive impairment were positively correlated with levels of LepRb protein and mRNA in the hippocampus and hypothalamus and hippocampus in obese rats facing chronic mild stress. Expand
Leptin: A potential novel antidepressant
Leptin, a hormone secreted from adipose tissue, was originally discovered to regulate body weight. The localization of the leptin receptor in limbic structures suggests a potential role for leptin inExpand
Hypolipidemic activity of Moringa oleifera Lam., Moringaceae, on high fat diet induced hyperlipidemia in albino rats
TLDR
The study demonstrates that M. oleifera possesses a hypolipidemic effect and was found to increase the excretion of fecal cholesterol. Expand
Moringa oleifera offers a Multi-Mechanistic Approach for Management of Obesity in Rats
TLDR
Experimental evidence is provided for the anti-obesity effect of Moringa oleifera ethanol extract in management of obesity induced by high cholesterol diet in rats, which reinforces the advice recommending consumption of Moreda oLEifera to modulate obesity. Expand
Pioglitazone, a PPARγ agonist rescues depression associated with obesity using chronic unpredictable mild stress model in experimental mice
TLDR
Repetitive treatment with pioglitazone reversed the CUMS induced behavioral and biochemical alterations in HFD fed obese mice which atleast in part may be mediated through improving altered plasma glucose. Expand
Antioxidant and Antifatigue Properties of the Aqueous Extract of Moringa oleifera in Rats Subjected to Forced Swimming Endurance Test
TLDR
The antifatigue properties of M. oleifera extract are demonstrated by its ability to improve body energy stores and tissue antioxidant capacity and to reduce the tissue build-up of lactic acid. Expand
Evaluation of the antidepressant activity of Moringa oleifera alone and in combination with fluoxetine
TLDR
The results obtained in this study suggest that combined administration of MOE with low doses of fluoxetine or other SSRI drugs seems to have promising potential, and may have been invoked through the noradrenergic-serotonergic neurotransmission pathway. Expand
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