The Potential and Challenges of Exploiting the Vast But Dynamic Neoepitope Landscape for Immunotherapy

@inproceedings{Verdegaal2017ThePA,
  title={The Potential and Challenges of Exploiting the Vast But Dynamic Neoepitope Landscape for Immunotherapy},
  author={Els M E Verdegaal and Sjoerd H van der Burg},
  booktitle={Front. Immunol.},
  year={2017}
}
Somatic non-synonymous mutations in the DNA of tumor cells may result in the presentation of tumor-specific peptides to T cells. The recognition of these so-called neoepitopes now has been firmly linked to the clinical success of checkpoint blockade and adoptive T cell therapy. Following proof-of-principle studies in preclinical models there was a surge of strategies to identify and exploit genetically defined clonally expressed neoepitopes. These approaches assume that neoepitope availability… CONTINUE READING
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