The Potential Value and Toxicity of Chromium Picolinate as a Nutritional Supplement, Weight Loss Agent and Muscle Development Agent

@article{Vincent2003ThePV,
  title={The Potential Value and Toxicity of Chromium Picolinate as a Nutritional Supplement, Weight Loss Agent and Muscle Development Agent},
  author={J. Vincent},
  journal={Sports Medicine},
  year={2003},
  volume={33},
  pages={213-230}
}
  • J. Vincent
  • Published 2003
  • Chemistry, Medicine
  • Sports Medicine
The element chromium apparently has a role in maintaining proper carbohydrate and lipid metabolism in mammals. As this role probably involves potentiation of insulin signalling, chromium dietary supplementation has been postulated to potentially have effects on body composition, including reducing fat mass and increasing lean body mass. Because the supplement is absorbed better than dietary chromium, most studies have focused on the use of chromium picolinate [Cr(pic)3]. Cr(pic)3 has been… Expand
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Claims that supplementation of 200 microg of Cr as CrPic promotes weight loss and body composition changes are not supported. Expand
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TLDR
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Recent advances in the nutritional biochemistry of trivalent chromium
  • J. Vincent
  • Chemistry, Medicine
  • Proceedings of the Nutrition Society
  • 2004
TLDR
A mechanism for the action of chromodulin has recently been proposed and can serve as a potential framework for further studies to test the role of Cr in metabolism, as the molecule has been found to bind to activated insulin receptor, stimulating its kinase activity. Expand
A Dietary Supplement Containing Standardized Phaseolus vulgaris Extract Influences Body Composition of Overweight Men and Women
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Results indicate that Phaseolus vulgaris extract produces significant decrement in body weight and suggest decrements in fat mass in the face of maintained lean body mass and indicate the use of natural weight loss supplements could aid in the struggle against obesity. Expand
Chromium picolinate and conjugated linoleic acid do not synergistically influence diet- and exercise-induced changes in body composition and health indexes in overweight women.
TLDR
The use of a combined CP and CLA supplement for 3 months does not affect diet- and exercise-induced changes in weight and body composition or improve indexes of metabolic and cardiovascular health in young overweight women. Expand
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References

SHOWING 1-10 OF 93 REFERENCES
Effects of chromium on body composition and weight loss.
TLDR
Chromium is only a small part of the puzzle in the control of weight loss and body composition, and its effects, if present, will be small compared with those of exercise and a well-balanced diet. Expand
Chromium, Exercise, and Body Composition
TLDR
Recently, chromium has been touted as an agent for increasing lean body mass and decreasing percent body fat and the various studies that have been conducted to investigate the relationship of chromium with exercise and body composition are reviewed. Expand
The role of chromium in nutrition and therapeutics and as a potential toxin.
TLDR
The evidence for the potential toxicity of chromium supplements in contrast with its usefulness as a nutrient or therapeutic agent in the treatment or prevention of insulin resistance is reviewed. Expand
Efficacy of chromium supplementation in athletes: emphasis on anabolism.
TLDR
The restoration and maintenance of chromium stores via supplementation would promote optimal insulin efficiency, necessary for high-level athletic performance, but potential anabolic effects of enhanced insulin function would likely be marginal, and reports of short-term anabolic increases from the supplementation of an organic chromium compound need to be confirmed. Expand
Effects of chromium picolinate supplementation on insulin sensitivity, serum lipids, and body weight in dexamethasone-treated rats.
TLDR
The hypothesis that Cr supplementation can be considered to improve carbohydrate and lipid metabolism in patients receiving corticosteroid treatment is supported. Expand
In vivo distribution of chromium from chromium picolinate in rats and implications for the safety of the dietary supplement.
TLDR
The tissue distribution, urinary and fecal loss, and subcellular hepatocyte distribution and concentration of the labels suggest that [Cr(pic)(3)] has a lifetime of less than 1 day in vivo, minimizing the potential threat from the supplement itself. Expand
Effects of Exercise on Chromium Levels
TLDR
It is estimated that most individuals are not ingesting sufficient amounts of chromium in their diets, and the prudent course of action for athletes would be to ingest foods rich in chromium and perhaps take a multivitamin/mineral supplement containing no more than the ESADDI of Chromium. Expand
Effects of chromium picolinate supplementation on insulin sensitivity, serum lipids, and body composition in healthy, nonobese, older men and women.
TLDR
Chromium picolinate supplementation alone does not appear to improve insulin sensitivity, serum lipids, or change body composition in nonobese, healthy men and women of advanced age. Expand
Chromium supplementation and resistance training: effects on body composition, strength, and trace element status of men.
TLDR
It is suggested that routine chromium supplementation has no beneficial effects on body- composition change or strength gain in men and whether chromium supplements of individuals with diminished chromium nutriture facilitates propitious changes in body structure and function remains to be determined. Expand
Lack of toxicity of chromium chloride and chromium picolinate in rats.
TLDR
A lack of toxicity of trivalent Cr is demonstrated, at levels that are on a per kg basis, several thousand times the upper limit of the estimated safe and adequate daily dietary intake for humans. Expand
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