The Potential Value and Toxicity of Chromium Picolinate as a Nutritional Supplement, Weight Loss Agent and Muscle Development Agent

  title={The Potential Value and Toxicity of Chromium Picolinate as a Nutritional Supplement, Weight Loss Agent and Muscle Development Agent},
  author={John B. Vincent},
  journal={Sports Medicine},
The element chromium apparently has a role in maintaining proper carbohydrate and lipid metabolism in mammals. As this role probably involves potentiation of insulin signalling, chromium dietary supplementation has been postulated to potentially have effects on body composition, including reducing fat mass and increasing lean body mass. Because the supplement is absorbed better than dietary chromium, most studies have focused on the use of chromium picolinate [Cr(pic)3]. Cr(pic)3 has been… 
High-dose chromium(III) supplementation has no effects on body mass and composition while altering plasma hormone and triglycerides concentrations
The lack of an effect of the Cr(III) compound at these levels of administration clearly indicates that Cr( III) supplements do not have an effect on body composition at any reasonable dosage.
Benefits of chromium(III) complexes in animal and human health
Efficacy of Chromium(III) Supplementation on Growth, Body Composition, Serum Parameters, and Tissue Chromium in Rats
The results indicate that chromium nanocomposite has higher efficacy on growth and body composition compared to the traditional chromium agents.
A–Z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance Part 9
Part 9 of the series on dietary supplements includes summaries of three products which address these interests among other claimed benefits: choline bitartrate, chromium picolinate and cissus quandrangularis (CQ).
Recent advances in the nutritional biochemistry of trivalent chromium
  • J. Vincent
  • Biology
    Proceedings of the Nutrition Society
  • 2004
A mechanism for the action of chromodulin has recently been proposed and can serve as a potential framework for further studies to test the role of Cr in metabolism, as the molecule has been found to bind to activated insulin receptor, stimulating its kinase activity.
A Dietary Supplement Containing Standardized Phaseolus vulgaris Extract Influences Body Composition of Overweight Men and Women
Results indicate that Phaseolus vulgaris extract produces significant decrement in body weight and suggest decrements in fat mass in the face of maintained lean body mass and indicate the use of natural weight loss supplements could aid in the struggle against obesity.


Effects of chromium on body composition and weight loss.
Chromium is only a small part of the puzzle in the control of weight loss and body composition, and its effects, if present, will be small compared with those of exercise and a well-balanced diet.
Chromium, Exercise, and Body Composition
Recently, chromium has been touted as an agent for increasing lean body mass and decreasing percent body fat and the various studies that have been conducted to investigate the relationship of chromium with exercise and body composition are reviewed.
The role of chromium in nutrition and therapeutics and as a potential toxin.
The evidence for the potential toxicity of chromium supplements in contrast with its usefulness as a nutrient or therapeutic agent in the treatment or prevention of insulin resistance is reviewed.
Effects of chromium picolinate supplementation on insulin sensitivity, serum lipids, and body weight in dexamethasone-treated rats.
The hypothesis that Cr supplementation can be considered to improve carbohydrate and lipid metabolism in patients receiving corticosteroid treatment is supported.
In vivo distribution of chromium from chromium picolinate in rats and implications for the safety of the dietary supplement.
The tissue distribution, urinary and fecal loss, and subcellular hepatocyte distribution and concentration of the labels suggest that [Cr(pic)(3)] has a lifetime of less than 1 day in vivo, minimizing the potential threat from the supplement itself.
Effects of Exercise on Chromium Levels
It is estimated that most individuals are not ingesting sufficient amounts of chromium in their diets, and the prudent course of action for athletes would be to ingest foods rich in chromium and perhaps take a multivitamin/mineral supplement containing no more than the ESADDI of Chromium.
Effects of chromium picolinate supplementation on insulin sensitivity, serum lipids, and body composition in healthy, nonobese, older men and women.
Chromium picolinate supplementation alone does not appear to improve insulin sensitivity, serum lipids, or change body composition in nonobese, healthy men and women of advanced age.
Chromium supplementation and resistance training: effects on body composition, strength, and trace element status of men.
It is suggested that routine chromium supplementation has no beneficial effects on body- composition change or strength gain in men and whether chromium supplements of individuals with diminished chromium nutriture facilitates propitious changes in body structure and function remains to be determined.
Lack of toxicity of chromium chloride and chromium picolinate in rats.
A lack of toxicity of trivalent Cr is demonstrated, at levels that are on a per kg basis, several thousand times the upper limit of the estimated safe and adequate daily dietary intake for humans.
The effect of chromium picolinate on serum cholesterol and apolipoprotein fractions in human subjects.
Observations show that chromium picolinate is efficacious in lowering blood lipids in humans.