The Potential Role of Chemokines in Alzheimer's Disease Pathogenesis.

  title={The Potential Role of Chemokines in Alzheimer's Disease Pathogenesis.},
  author={Gholamreza Azizi and Nikoo Khannazer and Abbas Mirshafiey},
  journal={American journal of Alzheimer's disease and other dementias},
  volume={29 5},
Alzheimer's disease (AD) is a neurodegenerative disorder and leading cause of dementia, which begins with impaired memory. The neuropathological hallmarks of AD include destructive alterations of neurons by neurofibrillary tangles, neuritic amyloid plaques, and neuroinflammatory process in the brain. Chemokines have a major role in inflammatory cell attraction and glial cell activation and/or modulation in the central nervous system. Moreover, the clinical and immunopathological evidence could… CONTINUE READING
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