The Potential Impact of Bystander Effects on Radiation Risks in a Mars Mission

@inproceedings{Brenner2001ThePI,
  title={The Potential Impact of Bystander Effects on Radiation Risks in a Mars Mission},
  author={David J. Brenner and Carl D. Elliston},
  booktitle={Radiation Research},
  year={2001}
}
Abstract Brenner, D. J. and Elliston, C. D. The Potential Impact of Bystander Effects on Radiation Risks in a Mars Mission. Radiat. Res. 156, 612–617 (2001). Densely ionizing (high-LET) galactic cosmic rays (GCR) contribute a significant component of the radiation risk in free space. Over a period of a few months—sufficient for the early stages of radiation carcinogenesis to occur—a significant proportion of cell nuclei will not be traversed. There is convincing evidence, at least in vitro… 
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42 Citations
Highly Influential Citations
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Background Citations
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Methods Citations
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42 Citations

Fundamental space radiobiology.

  • G. Nelson
  • Physics
    Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology
  • 2003
Traditional concepts of dose and its associated normalization parameter, RBE (relative biological effectiveness), break down under experimental scrutiny, and probabilistic models of risk based on the number of particle traversals per cell may be more appropriate.

Effects of Very Low Fluences of High-Energy Protons or Iron Ions on Irradiated and Bystander Cells

The data suggest that at fluences of high-energy protons or iron ions less than about 5 cGy, the response in irradiated cell populations may be dominated by the bystander response.

Effects of low fluences of radiations found in space on cellular systems

  • K. Held
  • Physics
    International journal of radiation biology
  • 2009
This review will discuss selected issues related to cellular responses to the types of radiations found in space, with emphasis on comparison of cellular effects from high versus low linear energy transfer (LET) radiations and on effects that might be expected to predominate at the low radiation fluences characteristic of space, e.g., bystander effects and adaptive responses.

The AMERE project: Enabling real-time detection of radiation effects in individual cells in deep space

Harderian Gland Tumorigenesis: Low-Dose and LET Response

Theoretical modeling of the data show that a nontargeted effect model provides a better fit than the targeted effect model, providing important information at space-relevant doses of heavy ions.

Applications of particle microbeams in space radiation research.

  • M. Durante
  • Physics
    Journal of radiation research
  • 2009
Particle microbeams can deliver single charged particles of different charge and energy to single cells from different tissues, and microbeam studies are therefore very useful for improving current risk estimates for long-term space travel.

Modulation of modeled microgravity on radiation-induced bystander effects in Arabidopsis thaliana.

NEUDOSE: A CubeSat Mission for Dosimetry of Charged Particles and Neutrons in Low-Earth Orbit

The NEUtron DOSimetry & Exploration (NEUDOSE) CubeSat mission is introduced, which will provide new measurements of dose and space radiation quality factors to improve the accuracy of cancer risk projections for current and future space missions.

Health risks of space exploration: targeted and nontargeted oxidative injury by high-charge and high-energy particles.

Elucidation of the mechanisms underlying the cellular responses to HZE particles, particularly under reduced gravity and situations of exposure to additional radiations, such as protons, should be useful in reducing the uncertainty associated with current models for predicting long-term health risks of space radiation.

High Content Analysis of Human Fibroblast Cell Cultures after Exposure to Space Radiation

To assess the stress response in human fibroblasts that were sent into space with the Foton-M3 mission, a pluralistic setup to measure DNA damage and inflammation response is developed by combining global and local dosimetry, image cytometry and multiplex array technology, thereby maximizing the scientific output.

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