The Potential Benefits of Palmitoylethanolamide in Palliation: A Qualitative Systematic Review

  title={The Potential Benefits of Palmitoylethanolamide in Palliation: A Qualitative Systematic Review},
  author={Mellar P. Davis and Bertrand Behm and Zankhana Mehta and Carlos Fernandez},
  journal={American Journal of Hospice and Palliative Medicine{\textregistered}},
  pages={1134 - 1154}
Palmitoylethanolamide (PEA) is a nutraceutical endocannabinoid that was retrospectively discovered in egg yolks. Feeding poor children with known streptococcal infections prevented rheumatic fever. Subsequently, it was found to alter the course of influenza. Unfortunately, there is little known about its pharmacokinetics. Palmitoylethanolamide targets nonclassical cannabinoid receptors rather than CB1 and CB2 receptors. Palmitoylethanolamide will only indirectly activate classical cannabinoid… 

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