The Post-GWAS Era: From Association to Function.

  title={The Post-GWAS Era: From Association to Function.},
  author={M. Gallagher and A. Chen-Plotkin},
  journal={American journal of human genetics},
  volume={102 5},
  • M. Gallagher, A. Chen-Plotkin
  • Published 2018
  • Biology, Medicine
  • American journal of human genetics
  • During the past 12 years, genome-wide association studies (GWASs) have uncovered thousands of genetic variants that influence risk for complex human traits and diseases. Yet functional studies aimed at delineating the causal genetic variants and biological mechanisms underlying the observed statistical associations with disease risk have lagged. In this review, we highlight key advances in the field of functional genomics that may facilitate the derivation of biological meaning post-GWAS. We… CONTINUE READING
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