The Polycystic Ovary Syndrome and recent human evolution

@article{Corbett2013ThePO,
  title={The Polycystic Ovary Syndrome and recent human evolution},
  author={Stephen J Corbett and Laure Morin-Papunen},
  journal={Molecular and Cellular Endocrinology},
  year={2013},
  volume={373},
  pages={39-50}
}
Polycystic ovary syndrome: current status and future perspective.
TLDR
Limited research has been done that encompasses the entirety of PCOS spectrum, and the current status and possible future perspective will be discussed.
Evolutionary origins of polycystic ovary syndrome: An environmental mismatch disorder
TLDR
The most severe form of polycystic ovary syndrome (PCOS) is likely a result of interactions between genetic predispositions for PCOS and modern obesogenic environments, particularly in populations that are disproportionately affected by obesity and metabolic disorders.
Evolutionary determinants of polycystic ovary syndrome: part 1.
Polycystic Ovary Syndrome
TLDR
This chapter reviews different aspects of the disease, epidemiology, effect on menstrual cycle, hormonal implications, clinical manifestations, ultrasound findings, treatment options, and the effect on fertility.
Is polycystic ovary syndrome a 20th Century phenomenon?
Polycystic ovary syndrome as a plausible evolutionary outcome of metabolic adaptation
TLDR
This review integrates fundamental endocrine-metabolic changes in healthy, normal-weight PCOS women with similar PCOS-like traits present in animal models in which tissue differentiation is completed during fetal life as in humans to support the evolutionary concept that PCOS has common ancestral and developmental origins.
Evolutionary determinants of polycystic ovary syndrome: part 2.
Endometriosis and polycystic ovary syndrome are diametric disorders
TLDR
The diametric disorder hypothesis provides novel, unifying, proximate, and evolutionary explanations for endometriosis risk, synthesizes diverse lines of research concerning the two most common female reproductive disorders, and generates future avenues of research for improving the quality of life and health of women.
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It is proposed that the clinical and biochemical features of PCOS can arise as a consequence of genetically determined hypersecretion of androgens by the ovary during, or very likely long before, puberty, and a unifying, 'linear' model is suggested to explain the aetiology of the heterogeneous phenotype.
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TLDR
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TLDR
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TLDR
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