The Polycystic Ovary Syndrome and recent human evolution

  title={The Polycystic Ovary Syndrome and recent human evolution},
  author={Stephen J Corbett and Laure Morin-Papunen},
  journal={Molecular and Cellular Endocrinology},
Polycystic ovary syndrome: current status and future perspective.
Limited research has been done that encompasses the entirety of PCOS spectrum, and the current status and possible future perspective will be discussed.
Evolutionary origins of polycystic ovary syndrome: An environmental mismatch disorder
The most severe form of polycystic ovary syndrome (PCOS) is likely a result of interactions between genetic predispositions for PCOS and modern obesogenic environments, particularly in populations that are disproportionately affected by obesity and metabolic disorders.
Evolutionary determinants of polycystic ovary syndrome: part 1.
Polycystic Ovary Syndrome
This chapter reviews different aspects of the disease, epidemiology, effect on menstrual cycle, hormonal implications, clinical manifestations, ultrasound findings, treatment options, and the effect on fertility.
Is polycystic ovary syndrome a 20th Century phenomenon?
Polycystic ovary syndrome as a plausible evolutionary outcome of metabolic adaptation
This review integrates fundamental endocrine-metabolic changes in healthy, normal-weight PCOS women with similar PCOS-like traits present in animal models in which tissue differentiation is completed during fetal life as in humans to support the evolutionary concept that PCOS has common ancestral and developmental origins.
Evolutionary determinants of polycystic ovary syndrome: part 2.
Endometriosis and polycystic ovary syndrome are diametric disorders
The diametric disorder hypothesis provides novel, unifying, proximate, and evolutionary explanations for endometriosis risk, synthesizes diverse lines of research concerning the two most common female reproductive disorders, and generates future avenues of research for improving the quality of life and health of women.


Developmental origin of polycystic ovary syndrome - a hypothesis.
It is proposed that the clinical and biochemical features of PCOS can arise as a consequence of genetically determined hypersecretion of androgens by the ovary during, or very likely long before, puberty, and a unifying, 'linear' model is suggested to explain the aetiology of the heterogeneous phenotype.
Genetics of Ovarian Disorders: Polycystic Ovary Syndrome
Polycystic ovary syndrome is the commonest endocrine disorder in women of reproductive age, occurring in upwards of 5% of women, and there is strong evidence that genetic factors play a major part in the aetiology of PCOS.
Polycystic ovary syndrome: Syndrome XX?
Polycystic ovary syndrome: an ancient disorder?
Managing anovulatory infertility and polycystic ovary syndrome
This review will concentrate on the management of infertility and polycystic ovary syndrome, and the general practitioner should be able to start investigations and formulate a diagnosis before referral to a specialist in reproductive medicine.
The genetics of the polycystic ovary syndrome
  • M. Urbanek
  • Biology
    Nature Clinical Practice Endocrinology &Metabolism
  • 2007
Although past genetic studies of PCOS have yielded only modest results, resources and techniques have been assembled to remedy the major deficits of these early studies, promising that the next few years will be a very exciting and rewarding era for the genetic analysis ofPCOS.
Commentary: Polycystic ovary syndrome: a transgenerational evolutionary adaptation
Three hypotheses for evolutionary advantage are discussed and the question of why a gene that predisposes to anovulation, diabetes and heart disease might have perpetuated so frequently is addressed.
An evolutionary approach to explain the high frequency of the polycystic ovary syndrome (PCOS).
An evolutionary explanation for the high prevalence rate of PCOS, the most common endocrine disorder causing female infertility, is presented and the symptomatology ofPCOS is described and the high prevalences are explained by means of Darwinian medicine, kin selection and allomothering.
What is polycystic ovary syndrome? Are national views important?
This debate wishes to re-explore the current thinking on PCOS, with a particular emphasis on the British and European perspective and invite others to contribute to the discussion which could form the basis for an international consensus.
Persistence pays off for PCOS gene prospectors.
It can be assumed that similar genes or gene networks may be involved in PCOS across populations, despite phenotypic differences in its expression among different populations.