The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae

@article{Charles1998ThePK,
  title={The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae},
  author={Julia F Charles and Sue L Jaspersen and Rachel L. Tinker-Kulberg and Lena H. Hwang and Alex Szidon and David O. Morgan},
  journal={Current Biology},
  year={1998},
  volume={8},
  pages={497-507}
}
BACKGROUND Following chromosome segregation in anaphase, ubiquitin-dependent degradation of mitotic cyclins contributes to the exit from mitosis. A key step in this process is catalyzed by a ubiquitin-protein ligase known as the anaphase-promoting complex (APC), the regulation of which is poorly understood. The Polo-related protein kinase Cdc5 in… CONTINUE READING