The Polo-like kinase Plx1 interacts with and inhibits Myt1 after fertilization of Xenopus eggs.

@article{Inoue2005ThePK,
  title={The Polo-like kinase Plx1 interacts with and inhibits Myt1 after fertilization of Xenopus eggs.},
  author={Daigo Inoue and Noriyuki Sagata},
  journal={The EMBO journal},
  year={2005},
  volume={24 5},
  pages={1057-67}
}
During the meiotic cell cycle in Xenopus oocytes, p90(rsk), the downstream kinase of the Mos-MAPK pathway, interacts with and inhibits the Cdc2 inhibitory kinase Myt1. However, p90(rsk) is inactivated after fertilization due to the degradation of Mos. Here we show that the Polo-like kinase Plx1, instead of p90(rsk), interacts with and inhibits Myt1 after fertilization of Xenopus eggs. At the M phase of the embryonic cell cycle, Cdc2 phosphorylates Myt1 on Thr478 and thereby creates a docking… CONTINUE READING

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