The Polo kinase Plk4 functions in centriole duplication

@article{Habedanck2005ThePK,
  title={The Polo kinase Plk4 functions in centriole duplication},
  author={Robert Habedanck and York-Dieter Stierhof and Christopher J Wilkinson and Erich A. Nigg},
  journal={Nature Cell Biology},
  year={2005},
  volume={7},
  pages={1140-1146}
}
The human Polo-like kinase 1 (PLK1) and its functional homologues that are present in other eukaryotes have multiple, crucial roles in meiotic and mitotic cell division1,2. By contrast, the functions of other mammalian Polo family members remain largely unknown. Plk4 is the most structurally divergent Polo family member; it is maximally expressed in actively dividing tissues and is essential for mouse embryonic development3. Here, we identify Plk4 as a key regulator of centriole duplication… CONTINUE READING

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