The Polo kinase Plk4 functions in centriole duplication

  title={The Polo kinase Plk4 functions in centriole duplication},
  author={Robert Habedanck and York Stierhof and Christopher J Wilkinson and Erich A. Nigg},
  journal={Nature Cell Biology},
The human Polo-like kinase 1 (PLK1) and its functional homologues that are present in other eukaryotes have multiple, crucial roles in meiotic and mitotic cell division. By contrast, the functions of other mammalian Polo family members remain largely unknown. Plk4 is the most structurally divergent Polo family member; it is maximally expressed in actively dividing tissues and is essential for mouse embryonic development. Here, we identify Plk4 as a key regulator of centriole duplication. Both… 

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