The Poisson Index: a new probabilistic model for protein-ligand binding site similarity

@article{Davies2007ThePI,
  title={The Poisson Index: a new probabilistic model for protein-ligand binding site similarity},
  author={J. R. Davies and R. M. Jackson and Kanti V. Mardia and Charles C. Taylor},
  journal={Bioinformatics},
  year={2007},
  volume={23 22},
  pages={3001-8}
}
MOTIVATION The large-scale comparison of protein-ligand binding sites is problematic, in that measures of structural similarity are difficult to quantify and are not easily understood in terms of statistical similarity that can ultimately be related to structure and function. We present a binding site matching score the Poisson Index (PI) based upon a well-defined statistical model. PI requires only the number of matching atoms between two sites and the size of the two sites-the same… CONTINUE READING
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