The Plasmodium falciparum Vps4 homolog mediates multivesicular body formation.

@article{Yang2004ThePF,
  title={The Plasmodium falciparum Vps4 homolog mediates multivesicular body formation.},
  author={Mei Yang and Isabelle Coppens and Steve Wormsley and Pavlina Baevova and Heinrich C Hoppe and Keith A. Joiner},
  journal={Journal of cell science},
  year={2004},
  volume={117 Pt 17},
  pages={3831-8}
}
Members of the apicomplexan family of parasites contain morphologically unique secretory organelles termed rhoptries that are essential for host cell invasion. Rhoptries contain internal membranes, and thus resemble multivesicular bodies. To determine whether multivesicular body endosomal intermediates are formed in Apicomplexa, we used the Plasmodium falciparum homolog of the class E gene, Vps4, as a probe. Endogenous P. falciparum Vps4 (PfVps4) localized to the cytoplasm of P. falciparum… CONTINUE READING