The Plasmodium falciparum Cell-Traversal Protein for Ookinetes and Sporozoites as a Candidate for Preerythrocytic and Transmission-Blocking Vaccines

@inproceedings{Espinosa2017ThePF,
  title={The Plasmodium falciparum Cell-Traversal Protein for Ookinetes and Sporozoites as a Candidate for Preerythrocytic and Transmission-Blocking Vaccines},
  author={Diego A Espinosa and Joel Vega-Rodr{\'i}guez and Yevel Flores-Garcia and Amy R. Noe and Christian Mu{\~n}oz and Russell C Coleman and Torben Bruck and Keith Haney and Alex J Stevens and Diane M. Retallack and Jeff W. Allen and Thomas S. Vedvick and Christopher B Fox and Steven G Reed and Randall F. Howard and Ahmed Fouad M. Salman and Chris J Janse and Shahid M Khan and Fidel P. Zavala and Gabriel M. Gutierrez},
  booktitle={Infection and immunity},
  year={2017}
}
Recent studies have shown that immune responses against the cell-traversal protein for Plasmodium ookinetes and sporozoites (CelTOS) can inhibit parasite infection. While these studies provide important evidence toward the development of vaccines targeting this protein, it remains unknown whether these responses could engage the Plasmodium falciparum CelTOS in vivo Using a newly developed rodent malaria chimeric parasite expressing the P. falciparum CelTOS (PfCelTOS), we evaluated the… CONTINUE READING
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