The Plasmodium Circumsporozoite Protein, a Novel NF-κB Inhibitor, Suppresses the Growth of SW480

@article{Ding2012ThePC,
  title={The Plasmodium Circumsporozoite Protein, a Novel NF-$\kappa$B Inhibitor, Suppresses the Growth of SW480},
  author={Yan Ding and Xiao-bing Huang and Taiping Liu and Yong Fu and Zhangping Tan and Hong Zheng and Tao-li Zhou and Jigang Dai and Wenyue Xu},
  journal={Pathology \& Oncology Research},
  year={2012},
  volume={18},
  pages={895-902}
}
The blocking of NF-κB activation is a promising strategy for the treatment of colorectal cancer. The circumsporozoite protein (CSP), a key component of the sporozoite stage of the malaria parasite, was recently reported to block NF-κB activation in hepatocytes. Thus, we investigated the effect of the CSP on the growth of the human colon cancer cell line, SW480. We demonstrated that transfection with a recombinant plasmid expressing CSP inhibited the proliferation of SW480 in a dose-dependent… 
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