The Plasma Concentration of Medroxyprogesterone Acetate and Ovarian Function During Treatment with Medroxyprogesterone Acetate in 5 and 10 mg Doses

@article{Wikstrm1984ThePC,
  title={The Plasma Concentration of Medroxyprogesterone Acetate and Ovarian Function During Treatment with Medroxyprogesterone Acetate in 5 and 10 mg Doses},
  author={A. Wikstr{\"o}m and B. Green and E. Johansson},
  journal={Acta Obstetricia et Gynecologica Scandinavica},
  year={1984},
  volume={63}
}
Abstract. Peripheral plasma levels of medroxyprogesterone acetate (MPA) were determined by radioimmunoassay in 5 women after oral administration of 5 and 10 mg medroxyprogesterone acetate daily. Peak levels of MPA in plasma were recorded within 1‐3 hours of taking the tablet, which indicates a rapid absorption from the gastro‐intestinal tract. The levels of medroxyprogesterone acetate 12 hours after taking of the 5 mg tablet‐remained constant throughout the 8 weeks of study. Peripheral plasma… Expand
Plasma concentrations of medroxyprogesterone acetate, estradiol and estrone following oral administration of Klimaxil, Trisequence/Provera and Divina. A randomized, single-blind, triple cross-over bioavailability study in menopausal women.
TLDR
There was no statistically significant difference between the drugs with respect to the estradiol levels, and Divina produced higher MPA concentrations than Klimaxil and the combination of Trisequence and Provera, although the mean AUC was not twice as high, as might have been expected. Expand
Effect of nomegestrol acetate, a new 19‐nor‐progesterone derivative, on pituitary‐ovarian function in women
TLDR
Results show an hypothalamic‐pituitary effect and suggest an ovarian action, both responsible for a potentially useful contraceptive property, in normally menstruating women treated with NOM Ac during the third consecutive cycle. Expand
Medroxyprogesterone acetate is a useful alternative to a gonadotropin-releasing hormone antagonist in oocyte donation: a randomized, controlled trial.
TLDR
The administration of MPA resulted in oocytes retrieval rates, endocrine profiles, viable embryo numbers, and pregnancy outcomes similar to those achieved with the GnRH antagonist, and MPA can be recommended for OS in oocyte donation because it permits a more patient-friendly approach. Expand
The efficacy of dydrogesterone use to suppress premature luteinizing hormone surge on cycle outcomes in controlled ovarian stimulation.
TLDR
Dydrogesterone can be used as an alternative to antagonist regimen in patients where embryo transfer is not planned in the same cycle, however, flexible regimen may not be appropriate in patients with diminished ovarian reserve as advanced follicular maturation and delayed suppressive effect of oral progesterone may cause premature ovulation. Expand
Comparison of Medroxyprogesterone Acetate With Cetrotide for Prevention of Premature Luteinizing Hormone Surges in Women Undergoing In Vitro Fertilization
TLDR
The results showed that in a woman undergoing COH, MPA as an oral drug was effective in the prevention of premature LH surge, and would help to establish a new method for ovarian stimulation in combination with embryo cryopreservation. Expand
Pharmacokinetics of oestrogens and progestogens.
TLDR
Among the progestogens, the progesterone derivatives have less effects on liver metabolism than the norethisterone derivatives (13-methyl-gonane derivatives and 13-ethyl-gonanes). Expand
Controlled Ovarian Stimulation Using Medroxyprogesterone Acetate and hMG in Patients With Polycystic Ovary Syndrome Treated for IVF
TLDR
The study showed that MPA has the advantages of an oral administration route, easy access, more control over LH levels, and a possible reduction in the incidence of moderate or severe OHSS with the MPA protocol should be viewed with caution as the data is small. Expand
Medroxyprogesterone acetate is an effective oral alternative for preventing premature luteinizing hormone surges in women undergoing controlled ovarian hyperstimulation for in vitro fertilization.
TLDR
The results show that MPA is an effective oral alternative for the prevention of premature LH surge in woman undergoing COH and will help establish a new regimen for ovarian stimulation in combination with embryo cryopreservation. Expand
Two-year prospective, randomized trial comparing an innovative twice-a-week progestin regimen with a continuous combined regimen as postmenopausal hormone therapy.
TLDR
Both regimens were similarly effective in improving compliance, symptom control, bleeding patterns, endometrial response, and lipid changes in postmenopausal women treated with transdermal E2 and a regimen of either intermittent or continuous dosing of progestin. Expand
Ovulation inhibition doses of progestins: a systematic review of the available literature and of marketed preparations worldwide.
TLDR
This review provides a comprehensive overview of all progestins ever tested for their ovulation inhibition potency and a summary of all preparations currently on the world market, including their regimens and their combinations with EE. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 17 REFERENCES
Pharmacokinetic observations on medroxyprogesterone acetate administered orally and intravaginally.
TLDR
The plasma levels of MPA are much lower than the d-norgestrel levels found after administration of smaller amounts of d-ngestrel, and this is probably explained by differences in compartmentalization of the drugs. Expand
Inhibition of the positive feedback of oestradiol during treatment with subcutaneous implants of d-norgestrel.
TLDR
The effects of d-norgestrel (40 mg), contained in a single dimethylp olysiloxane rod implanted subcutaneously in the gluteal region, were studied in 4 women and indicated that ovulation was suppressed. Expand
Medroxyprogesterone acetate, estradiol, FSH and LH in peripheral blood after intramuscular administration of Depo-ProveraR to women.
Abstract The peripheral blood levels of medroxyprogesterone acetate (MPA), estradiol, FSH and LH were measured after an intramuscular injection of 150 mg and 300 mg of Depo-Provera® in three women.Expand
The effect of various dosages of lynestrenol on the plasma levels of oestrogens and progesterone during the menstrual cycle in the rhesus monkey.
TLDR
The female rhesus monkey appears to require about ten times more lynestrenol per kg body weight than women for suppression of ovulation, however, the plasma levels of norethindrone, which is the active metabolite of lynstrenol, required for ovulation inhibition does not appear to be grossly different from those found in women. Expand
Hormonal effects of the 300 μg norethisterone (NET) minipill
TLDR
It is concluded that the relative length of follicular and luteal phases has a predictive value for the expected ovarian reaction to the NET minipill and the efficacy of the minipills might be increased by judicious selection of women exhibiting, during the pretreatment period, a high follicular to luteAl phase (F L ) ratio. Expand
Contraceptive rings; self-administered treatment governed by bleeding.
TLDR
Follicular activity was depressed during treatment as judged by plasma estradiol concentrations and no ovulations occurred, and systemic side effects in the form of aggressiveness, weight gain, acne and headache were noted by some of the subjects. Expand
Subdermal norethindrone pellets -- a method for contraception?
TLDR
This study indicates that the release of gestagen from four NET pellets was only initially high enough to completely inhibit ovulation and that to accomplish full contraceptive efficacy, a higher dose, i.e. more pellets, would have to be inserted. Expand
Hormonal profile of the cycle in 68 normally menstruating women.
TLDR
A combination of high initial estradiol levels with low LH levels is associated with relatively short cycles and the opposite combination with relatively long ones, and progesterone levels lower than this value or exceeding this value for a shorter period than 5 days are considered to reflect an insufficient or partially suppressed luteal function. Expand
Radioimmunoassay of oestrone and oestradiol in human and bovine peripheral plasma.
TLDR
Researchers in Sweden developed and assessed radioimmunoassays of estrone and estradiol in human and bovine peripheral plasma and found that in the 34 normal menstrual cycles observed in women a well defined midcycle estrogen peak always occurred; the luteal phase was less pronounced. Expand
A COMPREHENSIVE REVIEW OF INJECTABLE CONTRACEPTION WITH SPECIAL EMPHASIS ON DEPOT MEDROXYPROGESTERONE ACETATE
TLDR
A thorough review of the literature from studies with medroxyprogesterone acetate is presented, finding that injectable contraceptives do seem to cause a greater amount of menstrual disorders including amenorrhea than other types of contraception, they can however be used during lactation without effect of the lactating factor. Expand
...
1
2
...