The PilC adhesin of the Neisseria type IV pilus-binding specificities and new insights into the nature of the host cell receptor.

@article{Kirchner2005ThePA,
  title={The PilC adhesin of the Neisseria type IV pilus-binding specificities and new insights into the nature of the host cell receptor.},
  author={Marieluise Kirchner and Thomas F. Meyer},
  journal={Molecular microbiology},
  year={2005},
  volume={56 4},
  pages={945-57}
}
Type IV pili of Neisseria gonorrhoeae and Neisseria meningitidis mediate the first contact to human mucosal epithelial cells, an interaction which is also critical for the interaction with vascular endothelial cells. The PilC proteins have been characterized as the principal pilus-associated adhesin. Here we show that PilC2 exhibits a defined cell and tissue tropism, as it binds to human epithelial and endothelial cell lines, but not to human T cells or fibroblasts. Piliated gonococci and PilC2… CONTINUE READING
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