The Pif1 Helicase, a Negative Regulator of Telomerase, Acts Preferentially at Long Telomeres

@inproceedings{Phillips2015ThePH,
  title={The Pif1 Helicase, a Negative Regulator of Telomerase, Acts Preferentially at Long Telomeres},
  author={Jane Anna Phillips and Angela P. S. Chan and Katrin Paeschke and Virginia A. Zakian},
  booktitle={PLoS genetics},
  year={2015}
}
Telomerase, the enzyme that maintains telomeres, preferentially lengthens short telomeres. The S. cerevisiae Pif1 DNA helicase inhibits both telomerase-mediated telomere lengthening and de novo telomere addition at double strand breaks (DSB). Here, we report that the association of the telomerase subunits Est2 and Est1 at a DSB was increased in the absence of Pif1, as it is at telomeres, suggesting that Pif1 suppresses de novo telomere addition by removing telomerase from the break. To… CONTINUE READING

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