The Phytoestrogen Quercetin Impairs Steroidogenesis and Angiogenesis in Swine Granulosa Cells In Vitro

@article{Santini2009ThePQ,
  title={The Phytoestrogen Quercetin Impairs Steroidogenesis and Angiogenesis in Swine Granulosa Cells In Vitro},
  author={Sujen Eleonora Santini and Giuseppina Basini and Simona Bussolati and Francesca Grasselli},
  journal={Journal of Biomedicine and Biotechnology},
  year={2009},
  volume={2009}
}
Experimental evidence documents that nutritional phytoestrogens may interact with reproductive functions but the exact mechanism of action is still controversial. Since quercetin is one of the main flavonoids in livestock nutrition, we evaluated its possible effects on cultured swine granulosa cell proliferation, steroidogenesis, and redox status. Moreover, since angiogenesis is essential for follicle development, the effect of the flavonoid on Vascular Endothelial Growth Factor output by… 

Figures from this paper

Dietary bioflavonoid quercetin modulates porcine ovarian granulosa cell functions in vitro
TLDR
Results confirm the safety of quercetin in porcine ovarian granulosa cell model and suggest its possible concentration-dependent influence on ovarian functions through pathway that may involve progesterone, cyclin B1 and p53.
Overview of biological effects of Quercetin on ovary
TLDR
It seems that QUR as a supplementary factor has different activities for the treatment of different disorders and it also has bidirectional activities, however, further investigations are needed for understanding the efficacy of QUR in the treatment and improvement of gynecological patients.
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