The Phytoestrogen Genistein Affects Breast Cancer Cells Treatment Depending on the ERα/ERβ Ratio.

@article{Pons2016ThePG,
  title={The Phytoestrogen Genistein Affects Breast Cancer Cells Treatment Depending on the ERα/ERβ Ratio.},
  author={Daniel Gabriel Pons and Mercedes Nadal-Serrano and Margalida Torrens-Mas and Jordi Oliver and Pilar Roca},
  journal={Journal of cellular biochemistry},
  year={2016},
  volume={117 1},
  pages={218-29}
}
Genistein (GEN) is a phytoestrogen found in soybeans. GEN exerts its functions through its interaction with the estrogen receptors (ER), ERα and ERβ, and we previously reported that the ERα/ERβ ratio is an important factor to consider in GEN-treated breast cancer cells. The aim of this study was to investigate the effects of GEN in breast cancer cells with different ERα/ERβ ratio: MCF-7 (high ratio), T47D (low ratio), and MCF-7 overexpressing ERβ (MCF7 + ERβ) treated with cisplatin (CDDP… CONTINUE READING

Connections & Topics

Mentioned Connections BETA
GEN treatment provoked an increase in cell viability in MCF-7 cells and in the antioxidant enzymes protein levels in combination with the cytotoxic agents , decreasing ROS production ( CDDP + GEN and TAM+GEN ) and autophagy ( TAM + GEN ) or apoptosis ( CDDP + GEN and TAM + GEN ) .
Cell viability , ROS production , autophagy , apoptosis , antioxidant enzymes protein levels , and cell cycle were analyzed .
Cell viability , ROS production , autophagy , apoptosis , antioxidant enzymes protein levels , and cell cycle were analyzed .
Cell viability , ROS production , autophagy , apoptosis , antioxidant enzymes protein levels , and cell cycle were analyzed .
Cell viability , ROS production , autophagy , apoptosis , antioxidant enzymes protein levels , and cell cycle were analyzed .
Cell viability , ROS production , autophagy , apoptosis , antioxidant enzymes protein levels , and cell cycle were analyzed .
GEN treatment provoked an increase in cell viability in MCF-7 cells and in the antioxidant enzymes protein levels in combination with the cytotoxic agents , decreasing ROS production ( CDDP + GEN and TAM+GEN ) and autophagy ( TAM + GEN ) or apoptosis ( CDDP + GEN and TAM + GEN ) .
Cell viability , ROS production , autophagy , apoptosis , antioxidant enzymes protein levels , and cell cycle were analyzed .
Cell viability , ROS production , autophagy , apoptosis , antioxidant enzymes protein levels , and cell cycle were analyzed .
Cell viability , ROS production , autophagy , apoptosis , antioxidant enzymes protein levels , and cell cycle were analyzed .
Moreover GEN treatment enhanced the cell cycle S phase entry in CDDP+GEN- and TAM + GEN - treated MCF-7 cells and , in the case of CDDP + GEN , increased the proportion of cells in the G2/M phase and decreased it in the subG0 /G1 phase .
Moreover GEN treatment enhanced the cell cycle S phase entry in CDDP+GEN- and TAM + GEN - treated MCF-7 cells and , in the case of CDDP + GEN , increased the proportion of cells in the G2/M phase and decreased it in the subG0 /G1 phase .
Moreover GEN treatment enhanced the cell cycle S phase entry in CDDP+GEN- and TAM + GEN - treated MCF-7 cells and , in the case of CDDP + GEN , increased the proportion of cells in the G2/M phase and decreased it in the subG0 /G1 phase .
Cell viability , ROS production , autophagy , apoptosis , antioxidant enzymes protein levels , and cell cycle were analyzed .
Cell viability , ROS production , autophagy , apoptosis , antioxidant enzymes protein levels , and cell cycle were analyzed .
Cell viability , ROS production , autophagy , apoptosis , antioxidant enzymes protein levels , and cell cycle were analyzed .
Cell viability , ROS production , autophagy , apoptosis , antioxidant enzymes protein levels , and cell cycle were analyzed .
The aim of this study was to investigate the effects of GEN in breast cancer cells with different ERα/ERβ ratio : MCF-7 ( high ratio ) , T47D ( low ratio ) , and MCF-7 overexpressing ERβ ( MCF7 + ERβ ) treated with cisplatin ( CDDP ) , paclitaxel ( PTX ) or tamoxifen ( TAM ) .
The aim of this study was to investigate the effects of GEN in breast cancer cells with different ERα/ERβ ratio : MCF-7 ( high ratio ) , T47D ( low ratio ) , and MCF-7 overexpressing ERβ ( MCF7 + ERβ ) treated with cisplatin ( CDDP ) , paclitaxel ( PTX ) or tamoxifen ( TAM ) .
The aim of this study was to investigate the effects of GEN in breast cancer cells with different ERα/ERβ ratio : MCF-7 ( high ratio ) , T47D ( low ratio ) , and MCF-7 overexpressing ERβ ( MCF7 + ERβ ) treated with cisplatin ( CDDP ) , paclitaxel ( PTX ) or tamoxifen ( TAM ) .
The aim of this study was to investigate the effects of GEN in breast cancer cells with different ERα/ERβ ratio : MCF-7 ( high ratio ) , T47D ( low ratio ) , and MCF-7 overexpressing ERβ ( MCF7 + ERβ ) treated with cisplatin ( CDDP ) , paclitaxel ( PTX ) or tamoxifen ( TAM ) .
EstrogensContraindicated with diseaseMammary Neoplasms
GEN exerts its functions through its interaction with the estrogen receptors ( ER ) , ERα and ERβ , and we previously reported that the ERα/ERβ ratio is an important factor to consider in GEN - treated breast cancer cells .
Moreover GEN treatment enhanced the cell cycle S phase entry in CDDP+GEN- and TAM + GEN - treated MCF-7 cells and , in the case of CDDP + GEN , increased the proportion of cells in the G2/M phase and decreased it in the subG0 /G1 phase .
Genistein ( GEN ) is a phytoestrogen found in soybeans .
The Phytoestrogen Genistein Affects Breast Cancer Cells Treatment Depending on the ERα/ERβ Ratio .
Genistein ( GEN ) is a phytoestrogen found in soybeans .
Genistein ( GEN ) is a phytoestrogen found in soybeans .
Genistein ( GEN ) is a phytoestrogen found in soybeans .
Genistein ( GEN ) is a phytoestrogen found in soybeans .
The aim of this study was to investigate the effects of GEN in breast cancer cells with different ERα/ERβ ratio : MCF-7 ( high ratio ) , T47D ( low ratio ) , and MCF-7 overexpressing ERβ ( MCF7 + ERβ ) treated with cisplatin ( CDDP ) , paclitaxel ( PTX ) or tamoxifen ( TAM ) .
The aim of this study was to investigate the effects of GEN in breast cancer cells with different ERα/ERβ ratio : MCF-7 ( high ratio ) , T47D ( low ratio ) , and MCF-7 overexpressing ERβ ( MCF7 + ERβ ) treated with cisplatin ( CDDP ) , paclitaxel ( PTX ) or tamoxifen ( TAM ) .
GEN exerts its functions through its interaction with the estrogen receptors ( ER ) , ERα and ERβ , and we previously reported that the ERα/ERβ ratio is an important factor to consider in GEN - treated breast cancer cells .
The aim of this study was to investigate the effects of GEN in breast cancer cells with different ERα/ERβ ratio : MCF-7 ( high ratio ) , T47D ( low ratio ) , and MCF-7 overexpressing ERβ ( MCF7 + ERβ ) treated with cisplatin ( CDDP ) , paclitaxel ( PTX ) or tamoxifen ( TAM ) .
The aim of this study was to investigate the effects of GEN in breast cancer cells with different ERα/ERβ ratio : MCF-7 ( high ratio ) , T47D ( low ratio ) , and MCF-7 overexpressing ERβ ( MCF7 + ERβ ) treated with cisplatin ( CDDP ) , paclitaxel ( PTX ) or tamoxifen ( TAM ) .
All Topics