The Physiology, Signaling, and Pharmacology of Dopamine Receptors

@article{Beaulieu2011ThePS,
  title={The Physiology, Signaling, and Pharmacology of Dopamine Receptors},
  author={Jean-Martin Beaulieu and Raul R. Gainetdinov},
  journal={Pharmacological Reviews},
  year={2011},
  volume={63},
  pages={182 - 217}
}
G protein-coupled dopamine receptors (D1, D2, D3, D4, and D5) mediate all of the physiological functions of the catecholaminergic neurotransmitter dopamine, ranging from voluntary movement and reward to hormonal regulation and hypertension. Pharmacological agents targeting dopaminergic neurotransmission have been clinically used in the management of several neurological and psychiatric disorders, including Parkinson's disease, schizophrenia, bipolar disorder, Huntington's disease, attention… 

Figures and Tables from this paper

The Signaling and Pharmacology of the Dopamine D1 Receptor
TLDR
The current state of D1R drug development is addressed, including the pharmacology of newly developed non-catecholamine ligands, and the potential utility of D 1R-agonists in Parkinson's Disease and cognitive impairment is discussed.
Dopamine receptors – IUPHAR Review 13
TLDR
An update of the current knowledge regarding the complex biology, signalling, physiology and pharmacology of dopamine receptors is provided.
Dopamine Receptor Subtypes, Physiology and Pharmacology: New Ligands and Concepts in Schizophrenia
TLDR
The review summarizes the recent advances in the field, addressing the relevance of emerging new targets in schizophrenia in particular in relation to the dopamine – glutamate NMDA systems interactions.
Dopamine: Functions, Signaling, and Association with Neurological Diseases
TLDR
The aspects of dopamine as a catecholaminergic neurotransmitter and dopamine signaling pathways elicited through dopamine receptor activation in normal brain function are summarized and the potential involvement of these signaling pathways in evoking the onset and progression of some diseases in the nervous system are described.
The Behavioural Characterization of Dopamine D2 Receptor-related Protein-protein Interactions
TLDR
The disruption of D2R-DAT interaction was found to elevate voluntary movement in normal animals as well as in animals modeling acute dopamine depletion, which exhibited anti-psychotic actions in two animal models of Parkinson’s disease and schizophrenia.
Structural insights into the human D1 and D2 dopamine receptor signaling complexes
Beyond cAMP: The Regulation of Akt and GSK3 by Dopamine Receptors
TLDR
This work focuses on the molecular mechanisms involved, interacting partners, role of these signaling events in the action of antipsychotics, psychostimulants, and antidepressants as well as involvement in pathophysiology of schizophrenia, bipolar disorder, and Parkinson’s disease.
Allosteric interactions between catecholamine receptors and other G protein-coupled receptors: Pharmacological and functional characterization
TLDR
It is shown that DA and synthetic DA receptor ligands are able to bind to α2Rs and activate the same signaling pathways as NE, and further evidences are given that homodimers are the GPCR predominant species, and that allosteric interactions between orthosteric ligands of the different protomers of a G PCR heteromer, have important implications in the field of catecholamine receptor pharmacology.
Mechanisms for the Modulation of Dopamine D1 Receptor Signaling in Striatal Neurons
In the striatum, dopamine D1 receptors are preferentially expressed in striatonigral neurons, and increase the neuronal excitability, leading to the increase in GABAergic inhibitory output to
Dopamine receptor signaling in the forebrain
TLDR
Abnormal DA signaling in these circuits is associated with Parkinson disease, dystonia, schizophrenia, drug addiction, and attention-deficit disorders and the manifestations of these conditions reflect both the direct effects of impaired DA receptor signaling and DA receptor-triggered plastic changes in striatal and cortical synapses.
...
...

References

SHOWING 1-10 OF 440 REFERENCES
The dopamine D4 receptor: biochemical and signalling properties
TLDR
This work focuses on the dopamine D4 receptor, which contains an important polymorphism in its third intracellular loop and has been the subject of numerous studies investigating links with several brain disorders, such as attention-deficit hyperactivity disorder and schizophrenia.
Dopamine receptors: from structure to function.
TLDR
Target deletion of several of these dopamine receptor genes in mice should provide valuable information about their physiological functions and provide unequivocal evidence for the involvement of one of these receptors in the etiology of various central nervous system disorders.
Akt/GSK3 signaling in the action of psychotropic drugs.
TLDR
Investigations of the mechanism by which D2 dopamine receptors regulate Akt/GSK3 signaling strongly support the physiological relevance of a new modality of G protein-coupled receptor (GPCR) signaling involving the multifunctional scaffolding protein beta-arrestin 2.
The Akt-GSK-3 signaling cascade in the actions of dopamine.
Dopaminergic signaling in dendritic spines.
[Dopamine receptor].
  • M. Okuda, S. Togashi
  • Biology, Psychology
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme
  • 1990
Dopamine Receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous ligand for
The dopamine D3 receptor: a therapeutic target for the treatment of neuropsychiatric disorders.
TLDR
The D(3) receptor mediates behavioral abnormalities elicited by glutamate/NMDA receptor blockade, which suggests D(2) receptor-selective antagonists as novel antipsychotic drugs and novel treatment options in PD, schizophrenia and drug addiction, which are awaiting evaluation in clinical trials.
Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1
TLDR
The cloning of a gene encoding a 477-amino-acid protein with strong homology to the cloned Dt receptor is reported here the existence of a dopamine D1-like receptor with these characteristics had not been predicted and may represent an alternative pathway for dopamine-mediated events and regulation of D2 receptor activity.
Dopaminergic Supersensitivity in G Protein-Coupled Receptor Kinase 6-Deficient Mice
Recent advances in the molecular biology of dopamine receptors.
TLDR
Dopamine mediates these diverse effects through interactions with specific receptor proteins, and one of the challenges has been to characterizing the structure, function, and elucidate their properties.
...
...