The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway

@article{Deczkowska2020ThePP,
  title={The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway},
  author={Aleksandra Deczkowska and Assaf Weiner and Ido Amit},
  journal={Cell},
  year={2020},
  volume={181},
  pages={1207-1217}
}

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Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model

TLDR
The role of sTREM2 is studied in a mouse model of Alzheimer’s disease, and it is found it reduces amyloid accumulation and increases the numbers of plaque-associated microglia which correlates with improved behavioural function in the mice.

New insights into the role of TREM2 in Alzheimer’s disease

TLDR
Increases in understanding of the involvement of TREM2 and microglia in AD development that may open new therapeutic strategies targeting the immune system to influence AD pathogenesis are summarized.
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