The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway

  title={The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway},
  author={Aleksandra Deczkowska and Assaf Weiner and Ido Amit},

TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target

It is discussed the possibility that TREM2 may be a key factor that links central and peripheral lipid metabolism under disease conditions, including AD, and this link may be due to impacts on the integrity of the blood–brain barrier.

TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation

A number of recent exciting and important reports provide insight into the function of two key gene products – TREM2 (Triggering Receptor Expressed On Myeloid Cells 2) and PLCγ2 (Phospholipase C gamma2) – in microglia, and their role in neurodegenerative disorders.

TREM2 Mediates Microglial Anti-Inflammatory Activations in Alzheimer’s Disease: Lessons Learned from Transcriptomics

The influence of Trem2 on balance of pro- and anti-inflammatory microglial activations from a perspective of AD mouse model transcriptomics is outlined and the roles of TREM2 in different stages of AD are speculated, which may shed light to the development of T REM2-targeted strategy for the prevention and treatment of this neurodegenerative disorder.

Keeping the liver fit with TREM2 during hepatic carcinogenesis

In humans, two genes on chromosome 6p21 encode the triggering receptors expressed on myeloid cells-1 (TREM1) and triggering receptor expressed on myeloid cells-2 (TREM2), members of the

Small molecule therapeutics for neuroinflammation-mediated neurodegenerative disorders.

An overview of recent progress on key microglia targets and discovery of small molecule compounds advancing in clinical trials to minimize neuroinflammation is provided.

Role of TREM2 in Alzheimer's Disease: A Long Road Ahead.

The role of soluble TREM2 as an effective biomarker and impending neuroprotection in AD is summarized and the strategies to develop therapeutic agents against T REM2 by employing its expression, function, and signalling pathways are focused on.



TREM2-Ligand Interactions in Health and Disease.

TREM2, Microglia, and Neurodegenerative Diseases.

Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model

The role of sTREM2 is studied in a mouse model of Alzheimer’s disease, and it is found it reduces amyloid accumulation and increases the numbers of plaque-associated microglia which correlates with improved behavioural function in the mice.

New insights into the role of TREM2 in Alzheimer’s disease

Increases in understanding of the involvement of TREM2 and microglia in AD development that may open new therapeutic strategies targeting the immune system to influence AD pathogenesis are summarized.