The Phox2b transcription factor coordinately regulates neuronal cell cycle exit and identity.

@article{Dubreuil2000ThePT,
  title={The Phox2b transcription factor coordinately regulates neuronal cell cycle exit and identity.},
  author={Val{\'e}rie Dubreuil and M R Hirsch and Alexandre Pattyn and Jean François Brunet and Christo Goridis},
  journal={Development},
  year={2000},
  volume={127 23},
  pages={5191-201}
}
In the vertebrate neural tube, cell cycle exit of neuronal progenitors is accompanied by the expression of transcription factors that define their generic and sub-type specific properties, but how the regulation of cell cycle withdrawal intersects with that of cell fate determination is poorly understood. Here we show by both loss- and gain-of-function experiments that the neuronal-subtype-specific homeodomain transcription factor Phox2b drives progenitor cells to become post-mitotic. In the… CONTINUE READING