The Phox (PX) domain proteins and membrane traffic.

  title={The Phox (PX) domain proteins and membrane traffic.},
  author={Li-Fong Seet and Wanjin Hong},
  journal={Biochimica et biophysica acta},
  volume={1761 8},
Phosphoinositides (PIs) are phosphorylated derivatives of phosphatidylinositol (PtdIns) that regulate many cellular and physiological processes. Most PIs act by serving as membrane docking sites for proteins harboring specific PI-binding domains so that the location and function of these proteins could be dynamically governed. The Phox (PX) domain represents a novel PI-binding module capable of regulating membrane targeting of about 47 mammalian proteins, 30 of which are tentatively referred to… CONTINUE READING

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