The Phospholipid Scramblases 1 and 4 Are Cellular Receptors for the Secretory Leukocyte Protease Inhibitor and Interact with CD4 at the Plasma Membrane

@article{Py2009ThePS,
  title={The Phospholipid Scramblases 1 and 4 Are Cellular Receptors for the Secretory Leukocyte Protease Inhibitor and Interact with CD4 at the Plasma Membrane},
  author={B{\'e}n{\'e}dicte Py and St{\'e}phane Basmaciogullari and J{\'e}r{\^o}me Bouchet and M Tobias Zarka and Ivan C Moura and Marc Benhamou and Renato C Monteiro and Hakim Hocini and Ricardo Madrid and Serge B{\'e}nichou},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={6692 - 6696}
}
Secretory leukocyte protease inhibitor (SLPI) is secreted by epithelial cells in all the mucosal fluids such as saliva, cervical mucus, as well in the seminal liquid. At the physiological concentrations found in saliva, SLPI has a specific antiviral activity against HIV-1 that is related to the perturbation of the virus entry process at a stage posterior to the interaction of the viral surface glycoprotein with the CD4 receptor. Here, we confirm that recombinant SLPI is able to inhibit HIV-1… CONTINUE READING
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