The Phospholipase C-IP3 Pathway is Involved in Muscarinic Antinociception

@article{Galeotti2003ThePC,
  title={The Phospholipase C-IP3 Pathway is Involved in Muscarinic Antinociception},
  author={Nicoletta Galeotti and Alessandro Bartolini and Carla Ghelardini},
  journal={Neuropsychopharmacology},
  year={2003},
  volume={28},
  pages={888-897}
}
The cellular events involved in muscarinic analgesia were investigated in the mouse hot-plate test. Intracerebroventricular (i.c.v.) pretreatment with antisense oligonucleotides (aODNs) against the α subunit of Gq and G11 proteins prevented the analgesia induced by physostigmine and oxotremorine. Furthermore, administration of the phospholipase C (PLC) inhibitor U-73122, as well as the injection of an aODN complementary to the sequence of PLCβ1, antagonized the increase of the pain threshold… CONTINUE READING

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