The Phosphatidylinositol 3-Kinase / AKT Kinase Pathway in Multiple Myeloma Plasma Cells : Roles in Cytokine-dependent Survival and Proliferative Responses 1

@inproceedings{Tu2000TheP3,
  title={The Phosphatidylinositol 3-Kinase / AKT Kinase Pathway in Multiple Myeloma Plasma Cells : Roles in Cytokine-dependent Survival and Proliferative Responses 1},
  author={Yiping Tu and Agnes Gardner and Alan Lichtenstein},
  year={2000}
}
Interleukin 6 (IL-6) and insulin-like growth factor I (IGF-I) induce proliferative and antiapoptotic responses in multiple myeloma (MM) plasma cells. Because these cytokines may activate the phosphatidylinositol 3-kinase (PI 3-K)/AKT kinase pathway in other cell types, we investigated the role of PI 3-K/AKT in MM cell responses. IGF-I effectively activated PI 3-K in 8226 and OCI-My5 MM cells, but IL-6 was ineffective. However, IL-6 successfully activated PI 3-K in AF-10 MM cells and IL-6… CONTINUE READING