The Pheromone Androstenol (5α-Androst-16-en-3α-ol) Is a Neurosteroid Positive Modulator of GABAA Receptors

@article{Kaminski2006ThePA,
  title={The Pheromone Androstenol (5$\alpha$-Androst-16-en-3$\alpha$-ol) Is a Neurosteroid Positive Modulator of GABAA Receptors},
  author={Rafal M. Kaminski and Herbert Ryan Marini and Pavel I Ortinski and Stefano Vicini and Michael A. Rogawski},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2006},
  volume={317},
  pages={694 - 703}
}
Androstenol is a steroidal compound belonging to the group of odorous 16-androstenes, first isolated from boar testes and also found in humans. Androstenol has pheromone-like properties in both animals and humans, but the molecular targets of its pheromonal activity are unknown. Androstenol is structurally similar to endogenous A-ring reduced neurosteroids that act as positive modulators of GABAA receptors. Here we show that androstenol has neurosteroid-like activity as a GABAA receptor… 
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