The Pharmacology of Tramadol

@article{Dayer2012ThePO,
  title={The Pharmacology of Tramadol},
  author={Pierre Dayer and L Collart and Jules A. Desmeules},
  journal={Drugs},
  year={2012},
  volume={47},
  pages={3-7}
}
Summary(±)-Tramadol is a central analgesic with low affinity for opioid receptors. The rate of production of its M1 metabolite (O-demethyl tramadol) is influenced by debrisoquine-type polymorphism, and this metabolite shows a higher affinity for opioid receptors than the parent drug. Experimental and clinical data suggest that tramadol may also exert its analgesic effect through direct modulation of central monoaminergic pathways. Indeed, after a single oral dose, the role of the μ-receptor… 
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